Paget disease of bone pdf

Bone disease refers to the medical conditions which affect the bone. A bone disease is also called an “osteopathy”, but because the term osteopathy is often used to refer to an alternative health-care philosophy, use of the term can cause paget disease of bone pdf confusion.


Osteochondrodysplasia is a general term for a disorder of the development of bone and cartilage. This article about a disease of musculoskeletal and connective tissue is a stub.

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This 92 year-old male patient presented for assessment of sudden inability to move half his body. An incidental finding was marked thickening of the calvarium. The diploic space is widened and there are ill-defined sclerotic and lucent areas throughout.

The cortex is thickened and irregular. Paget’s disease of bone, also known as osteitis deformans or simply Paget’s disease, is caused by the excessive breakdown and formation of bone, followed by disorganised bone remodelling. This causes affected bone to weaken, resulting in pain, misshapen bones, fractures and arthritis in the joints near the affected bones. Rarely, it can develop into a primary bone cancer known as osteosarcoma.

Often Paget’s disease is localised to only a few bones in the body. The pelvis, femur, and lower lumbar vertebrae are the most commonly affected bones. Paget’s disease typically is localised, affecting just one or a few bones, as opposed to osteoporosis, for example, which usually affects all the bones in the body. A later phase of the disease is characterised by the replacement of normal bone marrow with highly vascular fibrous tissue.